Mild Cognitive Impairment in Parkinson's disease: Cognitive, Motor, and Behavioral Characterization Lead Investigator: Ann Sollinger Institution : E-Mail : absollinger@carilionclinic.org Proposal ID : 46 Proposal Description: Specific Aims: The proposed project will examine the clinical phenotype of mild cognitive impairment (MCI) in Parkinson???s disease (PD) using information collected as part of the Uniform Data Set (UDS). Although cognitive deficits have been found to be frequent in PD dementia (1, 2), the concept of MCI as defined and conceptualized by Petersen (3) has just begun to be applied to individuals from this population (4, 5). The current proposed project will seek to utilize the clinically rich UDS to further investigate the cognitive, behavioral, and motor phenotypes of MCI subtypes in PD. Our specific aims are as follows: Aim 1: Describe the pattern of cognitive dysfunction and particular subtypes of MCI in PD. Hypothesis: Patients with PD-MCI will predominately be categorized as multidomain MCI, specifically with impairments in executive functions and memory. Aim 2: Explore the relation between motor dysfunction as measured by UPDRS scores and cognitive status (normal, MCI, or dementia) in PD, as well as the relation to particular subtypes of MCI. Hypothesis: UPDRS scores in PD-MCI will be intermediate between the scores of PD with normal cognition and PD with dementia, and scores will be higher (indicative of greater extrapyramidal dysfunction) in multidomain vs. single domain MCI subtypes. Aim 3: Describe the neuropsychiatric symptoms of PD-MCI as measured by the Neuropsychiatric Inventory Questionnaire (NPI-Q) and relationship to MCI subtype. Hypothesis: NPI-Q scores of PD patients with MCI will be intermediate between PD with normal cognition and PD with dementia. Patients with multidomain MCI will have significantly greater NPI-Q scores (indicative of greater neuropsychiatric disturbance) than patients with single domain MCI.